H2N2V1, 1968, Analysis, bibRecord, 000059

Novel vaccines against influenza viruses

Identifieur interne : 000059 ( 1968/Analysis ); précédent : 000058; suivant : 000060

Novel vaccines against influenza viruses

Auteurs : Sang-Moo Kang [États-Unis] ; Jae-Min Song ; Richard W. Compans

Source :

Virus Research [ 0168-1702 ] ; 2011.

RBID : PMC:3401575

Abstract

Killed and live attenuated influenza virus vaccines are effective in preventing and curbing the spread of influenza epidemics when the strains present in the vaccines are closely matched with the predicted epidemic strains. These vaccines are primarily targeted to induce immunity to the variable major target antigen, hemagglutinin (HA) of influenza virus. However, current vaccines are not effective in preventing the emergence of new pandemic or highly virulent viruses. New approaches are being investigated to develop universal influenza virus vaccines as well as to apply more effective vaccine delivery methods. Conserved vaccine targets including the influenza M2 ion channel protein and HA stalk domains are being developed using recombinant technologies to improve the level of cross protection. In addition, recent studies provide evidence that vaccine supplements can provide avenues to further improve current vaccination.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401575

DOI: 10.1016/j.virusres.2011.09.037
PubMed: 21968298
PubMed Central: 3401575

Affiliations:

Links to Exploration step

PMC:3401575

Le document en format XML

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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Géorgie (États-Unis)</region>
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<wicri:cityArea>Center for Inflammation, Immunity & Infection, and Department of Biology, Georgia State University, Atlanta</wicri:cityArea>
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<author><name sortKey="Song, Jae Min" sort="Song, Jae Min" uniqKey="Song J" first="Jae-Min" last="Song">Jae-Min Song</name>
<affiliation><nlm:aff id="A2">Department of Microbiology and Immunology and Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, 30322</nlm:aff>
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<front><div type="abstract" xml:lang="en"><p id="P2">Killed and live attenuated influenza virus vaccines are effective in preventing and curbing the spread of influenza epidemics when the strains present in the vaccines are closely matched with the predicted epidemic strains. These vaccines are primarily targeted to induce immunity to the variable major target antigen, hemagglutinin (HA) of influenza virus. However, current vaccines are not effective in preventing the emergence of new pandemic or highly virulent viruses. New approaches are being investigated to develop universal influenza virus vaccines as well as to apply more effective vaccine delivery methods. Conserved vaccine targets including the influenza M2 ion channel protein and HA stalk domains are being developed using recombinant technologies to improve the level of cross protection. In addition, recent studies provide evidence that vaccine supplements can provide avenues to further improve current vaccination.</p>
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Serveur d'exploration H2N2

Novel vaccines against influenza viruses

Novel vaccines against influenza viruses

Source :

Abstract

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Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

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